| Identification | Back Directory | [Name]
DAP-81 | [CAS]
794466-17-4 | [Synonyms]
DAP-81
Acetamide, N-[4-[[4-[(2-benzoylphenyl)amino]-5-nitro-2-pyrimidinyl]amino]phenyl]- | [Molecular Formula]
C25H20N6O4 | [MDL Number]
MFCD32173672 | [MOL File]
794466-17-4.mol | [Molecular Weight]
468.46 |
| Hazard Information | Back Directory | [Description]
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations. |
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