| Identification | Back Directory | [Name]
DICHLORISONE ACETATE | [CAS]
79-61-8 | [Synonyms]
Sch 5005
DICHLORISONE ACETATE
dichlorisone 21-acetate
21-Acetyloxy-9,11β-dichloro-17-hydroxypregna-1,4-diene-3,20-dione
9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate
1,4-PREGNADIEN-9-ALPHA, 11-BETA-DICHLORO-17,21-DIOL-3,20-DIONE 21-ACETATE
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11β)-
9ALPHA,11BETA-DICHLORO-17ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE
[2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
[2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate
acetic acid [2-[(9R,17R)-9,11-dichloro-17-hydroxy-3-keto-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester | [EINECS(EC#)]
201-213-3 | [Molecular Formula]
C23H28Cl2O5 | [MDL Number]
MFCD00133265 | [MOL File]
79-61-8.mol | [Molecular Weight]
455.37 |
| Chemical Properties | Back Directory | [Melting point ]
246-253 °C (decomp) | [alpha ]
D25 +162° (dioxane) | [Boiling point ]
596.2±50.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 4.35 mg/mL (9.55 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
11.94±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Originator]
Diloderm ,Schering,US,1960 | [Uses]
antipruretic | [Definition]
ChEBI:Dichlorisone is a corticosteroid hormone. | [Manufacturing Process]
A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21-
acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous
hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture
is stirred for 2 hours and poured into ice water. The crude product is filtered
and washed with water to give 1.12 g of solid material, which is recrystallized
from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4-
pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).
| [Brand name]
Diloderm (Schering). | [Therapeutic Function]
Antipruritic, Antihistaminic, Appetite stimulant | [storage]
Store at -20°C |
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