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ChemicalBook--->CAS DataBase List--->780006-30-6

780006-30-6

780006-30-6 Structure

780006-30-6 Structure
IdentificationBack Directory
[Name]

HO-PEG8-CH2COOH
[CAS]

780006-30-6
[Synonyms]

HO-PEG8-CH2COOH
[Molecular Formula]

C18H36O11
[MDL Number]

MFCD31656912
[MOL File]

780006-30-6.mol
[Molecular Weight]

428.47
Hazard InformationBack Directory
[Biological Activity]

HO-PEG8-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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