| Identification | Back Directory | [Name]
6-HYDROXY-7-METHOXYCOUMARIN | [CAS]
776-86-3 | [Synonyms]
ISOSCOPOLETIN
ISOSCOPOLETINE
7-Methoxyesculetin
6-O-Demethylscoparone
esculetin 7-methyl ether
6-HYDROXY-7-METHYLCOUMARIN
6-HYDROXY-7-METHOXYCOUMARIN
7-METHOXY-6-HYDROXYCOUMARIN
6-hydroxy-7-methoxychromen-2-one
6-hydroxy-7-methoxy-chromen-2-one
6-hydroxy-7-methoxy-2-benzopyrone
6-hydroxy-7-methoxy-2H-chromen-2-one
6-Hydroxy-7-methoxy-2H-1-benzopyran-2-one
ISOSCOPOLETIN (6-HYDROXY-7-METHYLCOUMARIN)
6-Hydroxy-7-methyl coumarin-(Isoscopoletin) -
7-Methoxyesculetin, Esculetin 7-methyl ether, Isoscopoletin | [EINECS(EC#)]
212-282-4 | [Molecular Formula]
C10H8O4 | [MDL Number]
MFCD00016976 | [MOL File]
776-86-3.mol | [Molecular Weight]
192.17 |
| Chemical Properties | Back Directory | [Melting point ]
206-208°C | [Boiling point ]
413.5±45.0 °C(Predicted) | [density ]
1.37 g/cm3 | [storage temp. ]
2-8°C
| [solubility ]
DMSO: soluble
| [form ]
Solid | [pka]
8.94±0.20(Predicted) | [color ]
Pale Beige to Light Beige | [LogP]
0.830 (est) | [CAS DataBase Reference]
776-86-3 |
| Hazard Information | Back Directory | [Description]
Isoscopolamine is an antiasthmatic drug, which has the effect of relaxing smooth muscle and antihistamine. It can be used clinically in patients with chronic bronchitis and bronchial asthma. | [Chemical Properties]
Yellow needle-like crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Dengzhanhua, Rhododendron. | [Uses]
Isoscopolamine has anti-inflammatory, antioxidant, improving myocardial ischemia, anti-arrhythmic effects. | [Definition]
ChEBI: Isoscopoletin is a hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone. It has a role as a plant metabolite. It is a hydroxycoumarin and an aromatic ether. It is functionally related to an esculetin. | [Biological Activity]
Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active ingredient in Artemisia argyi. It has a significant inhibitory effect on cell proliferation with IC50 values of 4.0 μM and 1.6 μM against human CCRF-CEM leukemia cells and drug-resistant subline CEM/ADR5000, respectively. It (6-Hydroxy-7-methoxycoumarin) has the activity of inhibiting HBV replication. | [storage]
4°C, protect from light |
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