| Identification | Back Directory | [Name]
3-(acetylamino)propanesulphonic acid | [CAS]
77337-76-9 | [Synonyms]
ACAMPROSATE
N-acetylhomotaurine
3-Acetylamino-1-propanesulfonic acid
3-(acetylamino)propanesulphonic acid
3-(Acetylamino)-1-propanesulfonic acid
1-Propanesulfonic acid,3-(acetylamino)-
3-(acetylamino)propanesulphonic acid USP/EP/BP | [EINECS(EC#)]
278-667-4 | [Molecular Formula]
C5H11NO4S | [MOL File]
77337-76-9.mol | [Molecular Weight]
181.21 |
| Hazard Information | Back Directory | [Originator]
Campral,Merck | [Uses]
Treatment
of alcohol dependency. | [Definition]
ChEBI: An organosulfonic acid that is propane-1-sulfonic acid substituted by an acetylamino group at position 3. | [Manufacturing Process]
In a 4 liter flask provided with stirring means, a bromine funnel and a
thermometer, 17.5% sodium hydroxide solution and aminopropanesulfonic
acid (homotaurine) are added.
After complete dissolution, at a temperature of between 25°-40°C, acetic
anhydride are added so as not to exceed a temperature of between 30°-40°C.
The mixture is then maintained at this temperature by heating for at least 1
h.
The solution is then concentrated in vacuum, the residue is redissolved in 2.5
L of distilled water and the mixture is concentrated again. The residue is then
dissolved in 1.6 L of distilled water, filtered, then concentrated almost
completely. Drying is terminated in an oven in vacuum. A colorless crystalline
powder of 3-acetylaminopropanesulfonate of sodium (sodium Nacetylhomotaurinate)
is obtained.
The 3-acetylaminopropanesulfonic acid may be produced by treatment of 3-
acetylaminopropanesulfonate of sodium with hydrochloric acid.
In practice it is usually used as calcium salt. | [Brand name]
Campral (Forest). | [Therapeutic Function]
Psychotropic |
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