| Identification | Back Directory | [Name]
sorivudine | [CAS]
77181-69-2 | [Synonyms]
YN-72
D01734
BvAraU
BV-araU
Bravavir
Brovavir
Sorivudin
sorivudine
Bravavir (tn)
Sorivudine (jan/usan/inn)
1-(β-D-Arabinofuranosyl)-5-[(E)-2-bromoethenyl]uracil
1-β-D-Arabinofuranosyl-5-[(1E)-2-bromoethenyl]-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 1-β-D-arabinofuranosyl-5-[(1E)-2-bromoethenyl]-
1-β-D-Arabinofuranosyl-5-[(E)-2-bromovinyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione | [Molecular Formula]
C11H13BrN2O6 | [MOL File]
77181-69-2.mol | [Molecular Weight]
349.13 |
| Chemical Properties | Back Directory | [Melting point ]
182° (Sakata, 1980); mp 195-200° (dec) (Machida, Sakata, 1983) | [alpha ]
D25 +0.5° (1N NaOH) | [density ]
1.979±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (716.07 mM) | [form ]
Solid | [pka]
8.37±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective
activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a
cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of
20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream
is also useful in the topical treatment of cutaneous HSV-1 infection, including
immunocompromised patients. It has been suggested that its antiviral activity may be
mediated by inhibition of DNA synthesis in virus infected cells.
Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism,
caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to
avoid hematological disorders. | [Originator]
Yamasa Shoyu (Japan) | [Uses]
Antiviral. | [Definition]
ChEBI: Sorivudine is an organic molecular entity. | [Brand name]
Bravavir (Bristol-Myers Squibb);Usevir. |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|