| Identification | Back Directory | [Name]
4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-, hydrate (1:1) | [CAS]
76463-67-7 | [Synonyms]
(RS)-AMPA (monohydrate)
4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-, hydrate (1:1) | [Molecular Formula]
C7H12N2O5 | [MOL File]
76463-67-7.mol | [Molecular Weight]
204.18 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water : 5 mg/mL (24.49 mM; ultrasonic and warming and heat to 60°C) |
| Hazard Information | Back Directory | [Biological Activity]
(RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors[1][2].
(RS)-AMPA monohydrate (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA monohydrate is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA monohydrate at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA monohydrate also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA monohydrate exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors[1]. | [References]
[1]. H?sli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62. [2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5. |
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