| Identification | Back Directory | [Name]
MEN 935 | [CAS]
75708-29-1 | [Synonyms]
MEN 935
3-[3-[(2-hydroxy-3-naphthalen-1-yloxypropyl)amino]-3-methylbutyl]-1H-benzimidazol-2-one | [Molecular Formula]
C25H29N3O3.ClH.H2O | [MDL Number]
MFCD01658791 | [MOL File]
75708-29-1.mol | [Molecular Weight]
473.998 |
| Hazard Information | Back Directory | [Originator]
Adimolol
hydrochloride
,ZYF Pharm
Chemical | [Uses]
Adimolol is an antihypertensive agent and a β-adrenoceptor blocker. | [Manufacturing Process]
A mixture consisting of 3 g of 1-(3-amino-3,3-dimethyl-n-propyl)
benzimidazolidinone-2, 3.3 g of 1-[naphthyl-(1)-oxyl]propylene-(2,3)-epoxide
and 12 ml of 98% ethanol were refluxed for three hours. Thereafter, the
ethanol was distilled off, the residue was taken up in some methanol, and the
solution was acidified with 1 N hydrochloric acid and then extracted with ethyl
acetate. The ethyl acetate was distilled out of the extract solution, and ether
and some water were added to the residue, whereupon a crystalline substance
separated out. The product was recrystallized from ethanol, yielding 60% of
theory of ()-1-(3-((2-hydroxy-3-(1-naphthyloxy)propyl)amino)-3-
methylbutyl)-2-benzimidazolinone, which had a melting point of 161°C.
In practice it is usually used as hydrochloride. | [Therapeutic Function]
Alpa- and Beta-adrenergic blocker |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|