| Identification | Back Directory | [Name]
360 A iodide | [CAS]
737763-37-0 | [Synonyms]
360 A iodide
360A (iodide)
3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium] diiodide | [Molecular Formula]
I- | [MOL File]
737763-37-0.mol | [Molecular Weight]
126.904 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; insoluble in EtOH; insoluble in DMSO | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
360a is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for g-quadruplex structures and selective telomerase inhibition in vitro assays. 360a is a g-quadruplex ligand, which can influence the consequence of g-quadruplex formation and/or stabilization. | [in vitro]
we found a s-phase accumulation in atm-proficient, but not in atm-deficient ebv-lymphocytes treated with 360a before induction of cell death. however, atm status did not modify cell cycle distribution in 360a-treated sv40-fibroblasts and hela cells compared to dmso treated controls [1]. dna-pkcs-dependent nhej was responsible for sister telomere fusions as a direct consequence of g-quadruplex formation and/or stabilization induced by 360a on parental telomere g strands. nhej and hr activation at telomeres altered mitotic progression in treated cells [2]. this compound was shown to display a potent affinity and selectivity for telomeric g-quadruplex dna over duplex dna and to induce delayed growth inhibition in ht1080 tumor cell line [3]. | [storage]
Store at -20°C |
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