| Identification | Back Directory | [Name]
12(S)-HETrE | [CAS]
72710-10-2 | [Synonyms]
12(S)-HETrE
12(S)-hydroxy-8(Z),10(E),14(Z)-eicosatrienoic acid
8,10,14-Eicosatrienoic acid, 12-hydroxy-, (8Z,10E,12S,14Z)- | [Molecular Formula]
C20H34O3 | [MOL File]
72710-10-2.mol | [Molecular Weight]
322.48 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miseble; DMSO: Miseble; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml |
| Hazard Information | Back Directory | [Description]
12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).1 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.1 | [Definition]
ChEBI: 12(S)-HETrE is a HETrE that is (8Z,10E,14Z)-icosatrienoic acid in which the hydroxy group is located at the 12(S)-posiiton. It has a role as a human xenobiotic metabolite. It is functionally related to an all-cis-icosa-8,11,14-trienoic acid. It is a conjugate acid of a 12(S)-HETrE(1-). | [References]
1. Ikei, K.N., Yeung, J., Apopa, P.L., et al. Investigations of human platelet-type 12-lipoxygenase: Role of lipoxygenase products in platelet activation J. Lipid Res. 53(12),2546-2559(2012). |
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