| Identification | Back Directory | [Name]
vadocaine | [CAS]
72005-58-4 | [Synonyms]
OR-K-242
Vadocaina
vadocaine
Vadocainum
N-(2-Methoxy-4,6-dimethylphenyl)-2-methyl-1-piperidinepropanamide | [Molecular Formula]
C18H28N2O2 | [MDL Number]
MFCD00866830 | [MOL File]
72005-58-4.mol | [Molecular Weight]
304.431 |
| Hazard Information | Back Directory | [Originator]
Vadocaine hydrochloride ,ZYF Pharm Chemical | [Manufacturing Process]
3-Chloro-4',6'-dimethyl-o-propananisidide was prepared by using 92.8 g
(0.615 mol) 4,6-dimethyl-o-anisidine and 86 g (0.68 mol) of 3-chloropropionyl
chloride, melting point 123-125°C. A mixture containing 40 g (0.165 mol) of
3-chloro-4',6'-dimethyl-o-propananisidide, 54.3 g of 3-methyl piperidine, and
330 ml of anhydrous benzene was heated for 72 hours at 65°C. 47.7 g (84.5%) of N-(2-methoxy-4,6-dimethylphenyl)-2-methyl-1-
piperidinepropanamide hydrochloride was obtained by deposition of product in
anhydrous acetone saturated with hydrogen chloride; melting point 192-193°C
(crystallization from a mixture isopropanol-acetone). | [Therapeutic Function]
Antitussive, Local anesthetic |
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