| Identification | Back Directory | [Name]
thielavin B | [CAS]
71950-67-9 | [Synonyms]
thielavin B
4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-methoxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-methoxy-2,5,6-trimethylphenyl ester | [MDL Number]
MFCD11111623 | [MOL File]
71950-67-9.mol |
| Hazard Information | Back Directory | [Description]
Thielavin B is a fungal metabolite that contains O-substituted salicylic acid. It inhibits cyclooxygenase, blocking both the conversion of arachidonic acid to Prostaglandin H2 (PGH2) and the conversion of PGH2 to PGE2 (, IC50s = 40 and 9 μM, respectively). Thielavin B also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase activity. | [Uses]
Thielavin B is a fungal metabolite closely related to thielavin A but reported to have a slightly different biochemical profile. Thielavins inhibit glucose-6-phosphatase. Thielavin B is a potent inhibitor of phospholipase C, and inhibits peptidoglycan formation and prostaglandin biosynthesis. | [Uses]
Thielavin B is a fungal metabolite of?Thielavia terricola that contains O-substituted salicylic acid. It is an inhibitor of viral reverse transcriptase and telomerase. | [General Description]
Natural product derived from fungal source. |
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