| Identification | Back Directory | [Name]
ARP100 | [CAS]
704888-90-4 | [Synonyms]
ARP100
MMP-2 Inhibitor III
N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide
N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide
2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide
Acetamide, 2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy- | [Molecular Formula]
C17H20N2O5S | [MDL Number]
MFCD09971105 | [MOL File]
704888-90-4.mol | [Molecular Weight]
364.42 |
| Questions And Answer | Back Directory | [Uses]
ARP 100 is a potent, dual inhibitor of MMP-12/MMP-13 targets, which are a family of zinc dependent endopeptidases known to play key roles in extracellular matrix (ECM) breakdown disorders, such as the two main forms of arthritis, rheumatoid arthritis (RA) and osteoarthritis (OA). |
| Hazard Information | Back Directory | [Biological Activity]
Selective inhibitor of MMP-2 (IC 50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC 50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells. | [storage]
Desiccate at -20°C |
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| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
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