| Identification | Back Directory | [Name]
Nsc66811 | [CAS]
6964-62-1 | [Synonyms]
Nsc66811
NSC 66811; NSC66811; NSC-66811
7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol
7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol
2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol
2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-
8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline | [Molecular Formula]
C23H20N2O | [MDL Number]
MFCD08823776 | [MOL File]
6964-62-1.mol | [Molecular Weight]
340.418 |
| Chemical Properties | Back Directory | [Melting point ]
143.0 to 147.0 °C | [Boiling point ]
529.5±45.0 °C(Predicted) | [density ]
1.235±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble in DMSO (up to 25 mg/ml). | [form ]
solid | [pka]
4.42±0.50(Predicted) | [color ]
White | [λmax]
250nm(EtOH)(lit.) | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
NSC 66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable. | [Uses]
NSC 66811 is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. NSC 66811 activates p53 in colon cancer cells. | [References]
1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
TCI Europe
|
| Tel: |
320-37350700 |
| Website: |
https://www.tcichemicals.com/de/de/index.html |
| Company Name: |
TCI AMERICA
|
| Tel: |
800-4238616 |
| Website: |
https://www.tcichemicals.com/en/us/index.html |
|