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ChemicalBook--->CAS DataBase List--->6953-61-3

6953-61-3

6953-61-3 Structure

6953-61-3 Structure
IdentificationBack Directory
[Name]

1-NAPHTHOHYDROXAMIC ACID
[CAS]

6953-61-3
[Synonyms]

NSC 57457
Naphthohydroxamicacid
1-NAPHTHOHYDROXAMIC ACID
a-Naphthohydroxamic acid
alpha-naphthohydroxamicacid
1-NAPHTHOHYDROXAMIC ACID 98+%
HDAC Inhibitor XIX, Compound 2
1-Naphthalenecarbohydroximic acid
n-hydroxy-1-naphthalenecarboxamid
N-HYDROXYNAPHTHALENE-1-CARBOXAMIDE
Naphthalene-1-carbohydroximic acid
N-Hydroxy-1-naphthalenecarboxamide
[Molecular Formula]

C11H9NO2
[MDL Number]

MFCD00059546
[MOL File]

6953-61-3.mol
[Molecular Weight]

187.19
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: ≥5mg/mL
[form ]

White solid
[color ]

white to tan
Safety DataBack Directory
[Risk Statements ]

52
[WGK Germany ]

3
[RTECS ]

QJ1894500
[HS Code ]

2928009090
Hazard InformationBack Directory
[Uses]

1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.
[Biochem/physiol Actions]

1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

1-NAPHTHOHYDROXAMIC ACID(6953-61-3)MS
1-NAPHTHOHYDROXAMIC ACID(6953-61-3)1HNMR
1-NAPHTHOHYDROXAMIC ACID(6953-61-3)13CNMR
1-NAPHTHOHYDROXAMIC ACID(6953-61-3)IR1
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