| Identification | Back Directory | [Name]
SU-11752 | [CAS]
688036-19-3 | [Synonyms]
SU-11752
1H-Pyrrole-3-propanoic acid, 5-[[1,2-dihydro-2-oxo-5-[(phenylamino)sulfonyl]-3H-indol-3-ylidene]methyl]-2,4-diethyl- | [Molecular Formula]
C26H27N3O5S | [MOL File]
688036-19-3.mol | [Molecular Weight]
493.57 |
| Hazard Information | Back Directory | [Description]
SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited. |
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