| Identification | Back Directory | [Name]
(±)-4-aminohex-5-enoic acid | [CAS]
68506-86-5 | [Synonyms]
CPP 109
(+/-)-Vigabatrin
SABRIL; Γ-VINYL-GABA
5-Hexenoic acid, 4-amino-
Vigabatrin, racemic mixture
(±)-4-aminohex-5-enoic acid
rac-VigabatrinDiscontinued See V253010
Vigabatrin hydrochloride salt, racemic mixture | [EINECS(EC#)]
270-929-6 | [Molecular Formula]
C6H11NO2 | [MDL Number]
MFCD00274577 | [MOL File]
68506-86-5.mol | [Molecular Weight]
129.16 |
| Chemical Properties | Back Directory | [Melting point ]
209℃ | [Boiling point ]
277.7±28.0 °C(Predicted) | [density ]
1.064±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
neat | [pka]
4.36±0.10(Predicted) | [color ]
Off-White | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
rac-Vigabatrin a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic. | [Definition]
ChEBI: Vigabatrin is a gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase It has a role as an anticonvulsant and an EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor. | [Biochem/physiol Actions]
Irreversible GABA transaminase inhibitor. Increases intracellular concentration of GABA in nerve endings; possesses antiepileptic activity. | [in vivo]
A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin[1]. | [storage]
Store at +4°C |
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