| Identification | Back Directory | [Name]
AROTINOLOL | [CAS]
68377-92-4 | [Synonyms]
Arotinolo
AROTINOLOL
Arottnolol
NSC 317940
Arotinolol free base
AROTINOLOL USP/EP/BP
5-(2-((3-(tert-Butylamino)
Arotinolol Solution, 100ppm
Arotinolol Solution, 1000ppm
2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole
5-[2-[[3-(tert-butylamino)-2-hydroxy-propyl]thio]thiazol-4-yl]thiophene-2-carboxamide
5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide
5-[2-[3-(tert-butylamino)-2-hydroxy-propyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide
2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-
2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, (+-)- | [Molecular Formula]
C15H21N3O2S3 | [MDL Number]
MFCD00865895 | [MOL File]
68377-92-4.mol | [Molecular Weight]
371.54 |
| Chemical Properties | Back Directory | [Melting point ]
148-149° | [Boiling point ]
599.8±60.0 °C(Predicted) | [density ]
1.35 | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.71±0.20(Predicted) | [color ]
Off-White to Pale Yellow |
| Hazard Information | Back Directory | [Originator]
Arotinolol,ZYF Pharm | [Uses]
Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension. | [Definition]
ChEBI: Arotinolol is a member of thiophenes and an aromatic amide. | [Manufacturing Process]
To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in
20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol,
12.64 g in 20 ml of methanol was added, while the
temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then
condensed to a half volume in vacuo. The residual solution, added with 100 ml
of water, was extracted with chloroform. The chloroform extract was washed
with water, dried over anhydrous magnesium sulfate and evaporated in vacuo
to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-
thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec.,
recrystallized from methanol/water).
In practice it is usually used as hydrochloride. | [Therapeutic Function]
Beta-adrenergic blocker |
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