| Identification | Back Directory | [Name]
KERATIN | [CAS]
68238-35-7 | [Synonyms]
K6L
K5B
K78
K6A
K35
K82
CK6A
CK6C
CK6D
HHA5
HKA5
KB36
KB20
KB40
KB38
KRT3
CK-78
KRT6L
KRT79
KRT78
KRT28
KRT6C
KRT6E
KRT80
KRT12
KRT6A
KRT73
KRT25
KRT6D
KRT26
KRT82
KRT35
KRTHA5
KRTHB2
KRT25B
KRT25A
C01431
K6IRS3
KRT25D
KERATIN
detoxin
Kerasol
Keratine
keratins
KRT6IRS3
MGC126074
MGC126075
cheratina
Keratin-5b
Keratin-35
Keratin-82
type I Ha5
Hair keratin
Cytokeratins
Cytokeratin-78
Keratec IFP-HMW
KERATIN USP/EP/BP
KERATIN, EPIDERMAL
Type-II keratin Kb22
Type-II keratin Kb40
type I cuticular Ha5
type II cuticular Hb2
type I cytoskeletal 26
type II cytoskeletal 3
type I cytoskeletal 28
type I cytoskeletal 25
type I cytoskeletal 12
type II cytoskeletal 80
type II cytoskeletal 73
type II cytoskeletal 6C
type II cytoskeletal 79
type II cytoskeletal 78
type II cytoskeletal 6A
Type II hair keratin Hb2
Keratin, Human Epidermal
keratin from human epidermis
ANTI-CDK8 antibody produced in mouse
Keratin solution from human epidermis
KERATIN FROM HUMAN EPIDERMIS 500 UL*
Anti-KRT6A antibody produced in rabbit
ANTI-KRT3 (CENTER) antibody produced in rabbit
ANTI-KRT6C (N-TERM) antibody produced in rabbit
ANTI-KRT28 (C-TERM) antibody produced in rabbit
ANTI-KRT12 (C-TERM) antibody produced in rabbit
ANTI-K2C78 (CENTER) antibody produced in rabbit
ANTI-KRT79 (CENTER) antibody produced in rabbit
ANTI-KRT80 (C-TERM) antibody produced in rabbit
ANTI-KRT6A (N-TERM) antibody produced in rabbit
ANTI-KRT73 (C-TERM) antibody produced in rabbit
ANTI-KRT35 (C-TERM) antibody produced in rabbit
ANTI-KRT25 (C-TERM) antibody produced in rabbit
ANTI-KRT26 (N-TERM) antibody produced in rabbit
ANTI-KRT82 (CENTER) antibody produced in rabbit | [EINECS(EC#)]
269-409-1 | [MDL Number]
MFCD00131434 |
| Chemical Properties | Back Directory | [Definition]
A class of natural fibrous proteins occurring in vertebrate animals and humans, they are characterized by their high content of several amino acids, especially cystine, arginine, and serine. They are generally harder than the fibrous collagen group of pro | [density ]
1.00 g/mL at 20 °C
| [storage temp. ]
2-8°C
| [form ]
urea solution
| [Odor]
Characteristic, slight | [Uses]
keratin is a surface-protective agent with film-forming and moisturizing action. Keratin is often used in cosmetics for its moisture-retention and protective effect. | [CAS DataBase Reference]
68238-35-7 | [EPA Substance Registry System]
Keratins (68238-35-7) |
| Questions And Answer | Back Directory | [Benifits for Skin]
Keratins are epithelial-specific intermediate filaments and play an important cytostructural role in cells,
in addition to cell functions such as motility, proliferation, and apoptosis. They also have a protective role
for epithelial cells, helping cells contend with environmental stressors such as mechanical insults. There
are over 50 different types of keratin proteins, highly conserved across mammals. Disorders in keratin
production often results in hyperkeratosis, or thickening of SC due to trauma. Topical keratins have been
shown to reduce the degree of keratodermas. Keratin can be extracted from human hair or sheep’s wool,
and is commonly used in skin moisturizers and topical hair strengthening agents.
Many studies have been conducted to show the beneficial effects of keratin on skin renewal. Woolderived
keratin has recently been shown to stimulate keratinocyte migration as well as types IV and
VII collagen expression in fibroblasts. This shows that treatment with keratin results in rejuvenation of
the epithelium as well as strengthening of the epithelial basement membrane. A new keratin-based
hydrogel was used on a patient with epidermolysis bullosa, and resulted in improved robustness of skin
and healing.115 A randomized trial comparing 3% keratin to control showed that keratin is effective on
disturbed skin.116 Another study showed that topical keratin treatment leads to higher skin elasticity and
capacitance. Keratins conjugated to liposomes made of internal wood lipids are more effective than topical
aqueous solutions.
Studies have also been conducted on the topical application of synthetic fibronectin-like peptides.
These, like keratin, smoothed the skin surface and also reduced hyperpigmentation of the skin. |
| Hazard Information | Back Directory | [Agricultural Uses]
Fibrous proteins are generally insoluble in water and consist of long, coiled strands or flat sheets which have strength and elasticity. Keratin and collagen come in this category. Keratin is present in hair and wool. It is characterized by the high contents of several amino acids, especially cystine, arginine and serine. Keratins are generally harder than the fibrous collagen. Keratins are insoluble in organic solvents, but absorb and hold water. | [General Description]
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the ′Mediator-like′ protein complexes and the basal transcription machinery. (provided by RefSeq) | [Biochem/physiol Actions]
Keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis. This diverse group of cytoskeletal scaffolding proteins form intermediate filament networks which provide structural support to keratinocytes that maintain the integrity of the skin. Expression of keratin genes is usually regulated by differentiation of the epidermal cells within the stratifying squamous epithelium. |
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