| Identification | Back Directory | [Name]
GW4869 | [CAS]
6823-69-4 | [Synonyms]
CS-2410
GW4869(1)
GW4869(2)
GW4869 2HCl
GW4869/GW-4869
GW69A， GW554869A
GW4869 USP/EP/BP
N-SMase Inhibitor
GW4869 dihydrochloride
GW 4869 (hydrochloride hydrate)
GW4869;GW 4869 HYDROCHLORIDE HYDRATE
N-SMase Inhibitor, GW4869 - CAS 6823-69-4 - Calbiochem
4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride
2-PropenaMide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-iMidazol-2-yl)phenyl]-, hydrochloride (1:2) | [Molecular Formula]
C30H29N6O3X | [MDL Number]
MFCD06411564 | [MOL File]
6823-69-4.mol | [Molecular Weight]
521.59 |
| Hazard Information | Back Directory | [Uses]
GW4869 has been used:
- as an inhibitor of neutral sphingomyelinase and exosome biogenesis
- to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production
- to determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats
| [General Description]
GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-α by plasmacytoid dendritic cells?(pDCs). | [Biochem/physiol Actions]
A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase) |
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