| Identification | Back Directory | [Name]
BENZIODARONE | [CAS]
68-90-6 | [Synonyms]
l2329
Dilaf
Corofam
carofam
Vasilar
algocor
amplivix
cardivix
2329labaz
Retrangor
NSC 82133
Dilacoron
dilafurane
dila-vasal
benziodaron
BENZIODARONE
Benzoiodarone
coronal-crinos
aethyl-2-(3’,5’-dijod-4’-oxybenzoyl)-3cumaron
3-(3,5-diiodo-4-hydroxybenzoyl)-2-ethyl-benzofura
2-Ethyl-3-(4-hydroxy-3,5-diiodobenzoyl)benzofuran
2-Ethyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran
2-Ethyl-3-(3,5-diiodo-4-hydroxybenzoyl)-3-couMarone
2-ethyl-3-(3’,5’-diiodo-4’-hydroxybenzoyl)-cumarone
3,5-diiodo-4-hydroxyphenyl2-ethyl-3-benzofuranylketone
ketone,3,5-diiodo-4-hydroxyphenyl2-ethyl-3-benzofuranyl
2-Ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl ketone
(2-Ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)Methanone
(2-ethylbenzofuran-3-yl)-(4-hydroxy-3,5-diiodo-phenyl)methanone
Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)-
(2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodophenyl)methanone
(2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodo-phenyl)methanone | [EINECS(EC#)]
200-695-2 | [Molecular Formula]
C17H12I2O3 | [MDL Number]
MFCD00868246 | [MOL File]
68-90-6.mol | [Molecular Weight]
518.08 |
| Chemical Properties | Back Directory | [Melting point ]
167° | [density ]
1.9173 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [color ]
Beige | [Water Solubility ]
5.881mg/L(20 ºC) | [CAS DataBase Reference]
68-90-6 |
| Hazard Information | Back Directory | [Uses]
A uricosuric drug. It is used to effectively to control hyperuricemia in renal transplantation. | [Originator]
Amplivix,Sigma-Tau | [Definition]
ChEBI:Benziodarone is an aromatic ketone. | [Manufacturing Process]
The starting product 2-ethyl-3-benzofuranyl p-hydroxyphenyl ketone
(benzaron) was prepared in 4 steps:
1. First step was a reaction of salicylic aldehyde with chloroacetone to produce
2-acetyl-1-benzofuran.
2. It was reduced by hydrazine hydrate in an alkaline medium by process of
Hyuang-Minlon, J.A.C.S., 1946, 68, 2487 to give 2-ethyl-1-benzofurane.
3. 2-Ethyl-3-(4-methoxybenzoyl)-1-benzofuran was obtained from 2-ethyl-1-
benzofuran and 4-methoxy-benzoylchloride in a presence of tin tetrachloride.
4. It was heated with pyridine hydrochloride at 200°-220°C to give 2-ethyl-3-
benzofuranyl p-hydroxyphenyl ketone (benzaron) as described in N.P.B.Hoi,
C.Beaudet; US Patent No. 3,012,042; Dec. 5, 1961.
Benzaron (1 part) was dissolved in a very slight excess of 3% caustic soda. To
this solution is gradually added a slight excess of iodine dissolved in a 25%
aqueous solution of potassium iodide. The resultant solution is acidified with a
20% solution of sodium bisulphite, centrifuged, washed with water and then
recrystallized in acetic acid to give of 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-
diiodophenyl ketone. MP: 167°C. | [Therapeutic Function]
Coronary vasodilator, Uricosuric |
| Safety Data | Back Directory | [HS Code ]
2906.19.5000 | [Safety Profile]
A poison bj7
intraperitoneal and intravenous routes.
Moderately toxic by ingestion. A flammable
liquid. When heated to decomposition it
emits toxic vapors of I-.
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TCI AMERICA
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| Company Name: |
TCI Chemicals
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021-67121386, 800-988-0390 |
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www.tcichemicals.com |
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