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ChemicalBook--->CAS DataBase List--->67909-49-3

67909-49-3

67909-49-3 Structure

67909-49-3 Structure
IdentificationBack Directory
[Name]

Dehydroevodiamine
[CAS]

67909-49-3
[Synonyms]

Dehydroevodiamine
14-Methyl-5(7H)-oxo-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazoline-14-ium
5,7,8,13-Tetrahydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium
8,13-Dihydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolinium inner salt
Indolo[2',3':3,4]pyrido[2,1-b]quinazolinium,8,13-dihydro-14-methyl-5-oxo-, inner salt
14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide
[EINECS(EC#)]

200-258-5
[Molecular Formula]

C19H15N3O
[MDL Number]

MFCD11656140
[MOL File]

67909-49-3.mol
[Molecular Weight]

301.35
Chemical PropertiesBack Directory
[Melting point ]

190-192℃
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
[form ]

powder
[color ]

Yellow
Hazard InformationBack Directory
[Chemical Properties]

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus.
[Uses]

Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo.
[Biological Activity]

Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages.
[Physiological effects]

Dehydroevodiamine has an antihypertensive and antitumor effects.
[in vitro]

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression.

Western Blot Analysis

Cell Line:

td>
RAW 264.7 macrophage cells
Concentration: 10 μM, 30 μM, 50 μM
Incubation Time: pretreated 2 hours
Result: Reduced iNOS and COX-2 expression and increased IκB-α expression.

RT-PCR

< td class="col1"> Cell Line: td>
RAW 264.7 macrophage cells
Concentration: 10 μM, 30 μM, 50 μM
Incubation Time: pretreated 2 hours
Result: Reduced iNOS and COX-2 mRNA expression.
[target]

TargetValue
NF-κB
()
COX-2
()
iNOS
()
PGE2
()
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