| Identification | Back Directory | [Name]
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE | [CAS]
67469-81-2 | [Synonyms]
CS-1078
GBR 12935 HCl
GBR-12935 2HCL
GBR 12935 (hydrochloride)
GBR 12935 DIHYDROCHLORIDE
GBR-2935(dihydrochloride)
GBR 12935 dihydrochloride, >=98%
1-(2-(BENZHYDRYLOXY)ETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE.2HCL
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2) | [Molecular Formula]
C28H36Cl2N2O | [MDL Number]
MFCD00083175 | [MOL File]
67469-81-2.mol | [Molecular Weight]
487.5 |
| Hazard Information | Back Directory | [Uses]
A very potent and selective inhibitor of dopamine uptake | [Definition]
ChEBI: A hydrochloride salt that is obtained by reaction of 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine with two equivalents of hydrogen chloride. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal memb
anes). | [Biochem/physiol Actions]
GBR 12935 inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (Ki = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450. | [storage]
Store at -20°C |
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