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ChemicalBook--->CAS DataBase List--->65144-34-5

65144-34-5

65144-34-5 Structure

65144-34-5 Structure
IdentificationBack Directory
[Name]

MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE
[CAS]

65144-34-5
[Synonyms]

SPCK
HLE INHIBITOR
MEOSUC-APPV-CMK
MEOSUC-AAPV-CMK
ELASTASE INHIBITOR III
Elastase Inhibitor, SPCK
MEOSUC-ALA-ALA-PRO-VAL-CMK
N-(METHOXYSUCCINYL)-L-ALA-L-ALA-L-PROL.&
MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE
methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL*CHLORO METHYL KETO
N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL CHLOROMETHYL KETONE
N(methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine CMK
N-(methoxysuccinyl)-L-ala-L-ala-L-prol.-L-val-chlorome.ket.
methoxysuccinyl-alanyl-alanyl-prolyl-valinechloromethylketone
N-(METHOXYSUCCINYL)-L-ALANYL-L-ALANYL-L-PROLYL-L-VALINE CHLOROMETHYLKETONE
L-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-
methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
[Molecular Formula]

C22H35ClN4O7
[MDL Number]

MFCD00077136
[MOL File]

65144-34-5.mol
[Molecular Weight]

502.99
Chemical PropertiesBack Directory
[Melting point ]

159-161 °C
[Boiling point ]

809.4±65.0 °C(Predicted)
[density ]

1.234±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

ethanol: 50 mg/mL, clear, colorless
[form ]

Solid
[pka]

13.05±0.20(Predicted)
[Sensitive ]

Moisture Sensitive
[BRN ]

6167019
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
[F ]

10
Hazard InformationBack Directory
[Uses]

A potent irreversible inhibitor of human leukocyte elastase
[Definition]

ChEBI: A tripeptide derived from methoxysuccinyl-Ala-Ala-Pro-Val by conversion of the terminal carboxy group to the corresponding chloromethyl ketone.
[General Description]

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is a tetrapeptide, cell-permeable and non-cytotoxic inhibitor.
[Biochem/physiol Actions]

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone acts as a competitive inhibitor of human leukocyte elastase (HLE).
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