天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->6385-02-0

6385-02-0

6385-02-0 Structure

6385-02-0 Structure
IdentificationBack Directory
[Name]

MECLOFENAMATE SODIUM
[CAS]

6385-02-0
[Synonyms]

ci583
Movens
C02996
meclomen
Meclonax
Meclofenamate
SODIUM MECLOFENAMATE
sodiummeclophenamate
MECLOFENAMATE SODIUM
MECLOFENAMATESODIUM,USP
meclofenamic acid sodium
MECLOFENAMATE SODIUM SALT
SodiuM MeclofenaMate 
Sodium Meclofenamate Hydrate
MECLOFENAMATE SODIUM HYDRATE
MECLOFENAMIC ACID SODIUM SALT
Meclofenamate Sodium (500 mg)
MECLOFENAMATE SODIUM USP/EP/BP
sodium meclofenamate (anhydrous)
Sodium Meclofenamate Monohydrate
MECLOFENAMIC ACID SODIUM SALT 99%
SodiumMeclofenamateMonohydrate>
MECLOFENAMIC ACID SODIUM SALT MONOHYDRATE
sodium,2-(2,6-dichloro-3-methylanilino)benzoate
Meclofenamate Sodium (Meclofenamic acid sodium)
sodium2-((2,6-dichloro-3-methylphenyl)amino)benzoate
n-(2,6-dichloro-m-tolyl)-anthranilicacimonosodiumsalt
sodium 2-(2,6-dichloro-3-methylanilino)benzoate hydrate
2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]BENZOIC ACID SODIUM SALT
2-((2,6-dichloro-3-methylphenyl)amino)-benzoicacimonosodiumsalt
Benzoic acid, 2-[(2,6-dichloro-3-Methylphenyl)aMino]-, sodiuM salt
2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]-BENZOIC ACID, MONOSODIUM SALT
2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, sodium salt (1:1)
Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt (1:1)
2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt monohydrate
2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic Acid Sodium Salt Meclofenamic Acid Sodium Salt
[EINECS(EC#)]

228-983-3
[Molecular Formula]

C14H10Cl2NO2.Na
[MDL Number]

MFCD00941475
[MOL File]

6385-02-0.mol
[Molecular Weight]

318.13
Chemical PropertiesBack Directory
[Melting point ]

287-291 °C
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

White solid.
[color ]

White to Off-White
[Water Solubility ]

Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
[Merck ]

14,5779
[Stability:]

Hygroscopic
Safety DataBack Directory
[WGK Germany ]

3
[RTECS ]

CB2975500
[HS Code ]

2922498050
Hazard InformationBack Directory
[Description]

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.
[Originator]

Meclomen,Warner Lambert,US,1980
[Uses]

antiinflammatory, antipyretic
[Definition]

ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
[Indications]

Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.
[Manufacturing Process]

A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.
[Brand name]

Meclomen (Parke-Davis).
[Therapeutic Function]

Antiinflammatory
[General Description]

Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.
[Biological Activity]

Dual 5-lipoxygenase (IC50=46.8 μM) and cyclooxygenase I and II inhibitor (IC50=0.6 μM). Clinically useful NSAID.
[Pharmacokinetics]

Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
Metabolism of meclofenamic acid..jpg
[Clinical Use]

Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.
Spectrum DetailBack Directory
[Spectrum Detail]

MECLOFENAMATE SODIUM(6385-02-0)1HNMR
MECLOFENAMATE SODIUM(6385-02-0)13CNMR
MECLOFENAMATE SODIUM(6385-02-0)IR1
MECLOFENAMATE SODIUM(6385-02-0)IR2
6385-02-0 suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: 571-88938639 +8617705817739 , +8617705817739
Website: https://www.dycnchem.com/
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490 , +8618058761490
Website: https://www.gihichemicals.com/
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135 , +8613564774135
Website:
Company Name: Shaanxi Dideu New Materials Co. Ltd
Tel: +86-18192503167 +86-18192503167 , +86-18192503167
Website:
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: ABCR GmbH & CO. KG
Tel: 49 721 95061 0
Website: www.abcr.de
Company Name: Aurazia Chem Laboratories Private Limited  
Tel: +91-9840924287 +91-8754492844
Website: www.www.NOWEBSITE
Company Name: Chemwill Asia Co.,Ltd.  
Tel: 86-21-51086038
Website: www.chemwill.com
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Website: http://www.jkchemical.com
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
Tel: 021-61259108 18621169109
Website: https://www.meryer.com/cn/index/
Tags:6385-02-0 Related Product Information
3653-48-3 95-81-8 64063-37-2 91-40-7 15307-93-4