| Identification | Back Directory | [Name]
Isoquinoline, 1,7-dichloro-4-Methoxy- | [CAS]
630423-36-8 | [Synonyms]
Asunaprevir N-1
Asunaprevir Intermediate 2
1,7-dichloro-4-Methoxyisoquinoline
Isoquinoline, 1,7-dichloro-4-Methoxy- | [Molecular Formula]
C10H7Cl2NO | [MDL Number]
MFCD17012717 | [MOL File]
630423-36-8.mol | [Molecular Weight]
228.075 |
| Chemical Properties | Back Directory | [Melting point ]
137.0 to 142.0 °C | [Boiling point ]
355.7±37.0 °C(Predicted) | [density ]
1.384±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
powder to crystal | [pka]
0.98±0.34(Predicted) | [color ]
White to Yellow to Orange |
| Hazard Information | Back Directory | [Uses]
1,7-Dichloro-4-methoxyisoquinoline acts as a reagent in the synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease. Preparation, SAR of methoxyisoquinoline derivatives and discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection. |
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