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ChemicalBook--->CAS DataBase List--->62777-90-6

62777-90-6

62777-90-6 Structure

62777-90-6 Structure
IdentificationBack Directory
[Name]

5,6ALPHA-DIHYDRO PGI2
[CAS]

62777-90-6
[Synonyms]

6α-Prostaglandin I1
5,6ALPHA-DIHYDRO PGI2
6ALPHA-PROSTAGLANDIN I1
RJADQDXZYFCVHV-WDONHGPHSA-N
6R,9ALPHA-EPOXY-11ALPHA,15S-DIHYDROXY-PROST-13E-EN-1-OIC ACID
(6R,13E,15S)-6,9α-Epoxy-11α,15-dihydroxyprost-13-en-1-oic acid
Prost-13-en-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (6R,9α,11α,13E,15S)- (9CI)
[Molecular Formula]

C20H34O5
[MDL Number]

MFCD00797658
[MOL File]

62777-90-6.mol
[Molecular Weight]

354.48
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: >10 (from (6b-PGI1); DMSO: >5 (from (6b-PGI1); Ethanol: >20 mg/ml (from (6b-PGI1); PBS pH 7.2: >80 μg (from (6b-PGI1)
[form ]

A crystalline solid
Hazard InformationBack Directory
[Description]

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response.1 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).2
[Definition]

ChEBI: 6alpha-Prostaglandin I1 is a prostaglandins I.
[storage]

Store at -20°C
[References]

1. Patrono, C., Rotella, C.M., Toccafondi, R.S., et al. Prostacyclin stimulates the adenylate cyclase system of human thyroid tissue Prostaglandins 22(1),105-115(1981).
2. Whittle, B.J.R., and Moncada, S. Prostacyclin and its analogues for the therapy of thromboembolic disorders Adv. Exp. Med. Biol. 164,193-209(1984).
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