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ChemicalBook--->CAS DataBase List--->61443-77-4

61443-77-4

61443-77-4 Structure

61443-77-4 Structure
IdentificationBack Directory
[Name]

8-hydroxyloxapine
[CAS]

61443-77-4
[Synonyms]

8-hydroxyloxapine
Loxapine 8-Hydroxy Impurity
2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol
8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol
Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
[Molecular Formula]

C18H18ClN3O2
[MOL File]

61443-77-4.mol
[Molecular Weight]

343.81
Chemical PropertiesBack Directory
[Melting point ]

212-215°C
[storage temp. ]

Amber Vial, -20°C Freezer, Under Inert Atmosphere
[solubility ]

DMSO: soluble
[form ]

A solid
[Stability:]

Light Sensitive
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302+H312+H332-H315-H319
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501
Hazard InformationBack Directory
[Description]

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).
[Chemical Properties]

Pale Yellow Solid
[Uses]

The inactive
[storage]

Store at -20°C
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