| Identification | Back Directory | [Name]
ACECLIDINE HYDROCHLORIDE | [CAS]
6109-70-2 | [Synonyms]
AceclidineHCl
Aceclidine hydochloride
ACECLIDINE HYDROCHLORIDE
3-acetoxyquinuclidinehydrochloride
3-Quinuclidinol acetate hydrochloride
Acetate-3-quinuclidinol Hydrochloride
quinuclidin-3-yl acetate hydrochloride
3-quinuclidinol,acetate(ester),hydrochloride
acetic acid quinuclidin-3-yl ester hydrochloride
1-Azabicyclo[2.2.2]oct-3-yl acetate hydrochloride
1-azabicyclo[2.2.2]octan-8-yl acetate hydrochloride
3-ACETYLOXY-1-AZABICYCLO[2,2,2]OCTANE, HYDROCHLORIDE
1-azabicyclo[2.2.2]octan-8-yl ethanoate hydrochloride
1-azabicyclo(2.2.2)octan-3-ol,acetate(ester),hydrochloride
3-Acetoxyquinuclidine hydrochloride, Aceclidine hydrochloride | [EINECS(EC#)]
228-071-5 | [Molecular Formula]
C9H16ClNO2 | [MDL Number]
MFCD00136230 | [MOL File]
6109-70-2.mol | [Molecular Weight]
205.68 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Powder | [Melting point ]
166°C | [storage temp. ]
-20°C Freezer | [solubility ]
H2O: ≥15mg/mL at ~60°C | [form ]
powder | [color ]
white to tan | [Water Solubility ]
H2O: ≥15mg/mL at~60°C | [Stability:]
Moisture Sensitive |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Powder | [Uses]
Aceclidine is a synthetic analogue of arecoline, a natural cholinomimetic alkaloid. Aceclidine acts as an agonist at cholinergic receptors and has therapeutic use to reduce intraocular pressure in glaucoma. | [Uses]
Glaucoma;Parasympatho- | [Biological Activity]
Aceclidine at a concentration of 5 and 50 μg is capable of enhancing the outflow facilityfollowing ciliary muscle disinsertion.''Aceclidine hydrochloride is a parasympathomimetic drug with weak anticholinesterase activity. It acts on cholinergic nerve-endingslowers intraocular pressure and potent therapeutic agent for open-angle glaucoma.''Aceclidine is a non-selective muscarinic acetylcholine receptor partial agonist th at is effective in reducing intraocular pressure. | [in vivo]
Aceclidine (1-10mg/kg, s.c.) hydrochloride reverses Hemicholinium-3 (HY-B2152) induces spatial learning and deficit in rats[4].
| [IC 50]
mAChR1; mAChR3 |
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