| Identification | Back Directory | [Name]
3-CARBETHOXYUMBELIFERONE | [CAS]
6093-71-6 | [Synonyms]
YZ9
AURORA 9226
AKOS BBS-00008132
3-CARBETHOXYUMBELIFERONE
ETHYL 3-UMBELLIFERYLCARBOXYLATE
ethyl umbelliferone-3-carboxylate
Ethyl 7-Hydroxycoumarin-3-carboxylate
Ethyl7-Hydroxycoumarin-3-carboxylate>
ethyl 7-hydroxy-2-oxochromene-3-carboxylate
UMBELLIFERONE 3-CARBOXYLIC ACID ETHYL ESTER
3-CARBETHOXYUMBELIFERONE ISO 9001：2015 REACH
Ethyl 7-hydroxy-2-oxo-2H-chroMene-3-carboxylate
7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID ETHYL ESTER
Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate
7-Hydroxycoumarin-3-carboxylic acid ethyl ester ,98%
2H-1-Benzopyran-3-carboxylic acid, 7-hydroxy-2-oxo-, ethyl ester
3-CARBETHOXYUMBELIFERONE7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester | [Molecular Formula]
C12H10O5 | [MDL Number]
MFCD00017641 | [MOL File]
6093-71-6.mol | [Molecular Weight]
234.2 |
| Chemical Properties | Back Directory | [Melting point ]
170.0 to 174.0 °C | [Boiling point ]
448.3±45.0 °C(Predicted) | [density ]
1.397±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
7.32±0.20(Predicted) | [color ]
white to beige | [λmax]
398nm(EtOH)(lit.) | [CAS DataBase Reference]
6093-71-6 |
| Hazard Information | Back Directory | [Chemical Properties]
Brown solid | [Uses]
Z9 is a potent inhibitor of PFKFB3, a member of 6-phosphofructo-2-kinases family. It avidly competes with fructose 6-phosphate (F6P) at PFKFB3. YZ9 is also cell permeable, inhibiting the growth of HeLa cells. | [Biological Activity]
YZ9 is a 5678-tetrahydroxy-2-(4-hydroxyphenyl) chromen-4-one (N4A) inhibitor.''YZ9 is a potent inhibitor of PFKFB3 (6-phosphfructo-2-kinase/fructose-2,6-bisphosphatase) with an IC50 = 183 nM. PFKFB3 is over expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphatewhich can potentiate PFK1 activityenhancing glycolysis in tumor cells. YZ9 dose dependently inhibits proliferation of HeLa cells. | [storage]
Store at -20°C |
|
| Company Name: |
TCI Europe
|
| Tel: |
320-37350700 |
| Website: |
https://www.tcichemicals.com/de/de/index.html |
| Company Name: |
TCI AMERICA
|
| Tel: |
800-4238616 |
| Website: |
https://www.tcichemicals.com/en/us/index.html |
|