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ChemicalBook--->CAS DataBase List--->6080-33-7

6080-33-7

6080-33-7 Structure

6080-33-7 Structure
IdentificationBack Directory
[Name]

SINOMENINE HYDROCHLORIDE
[CAS]

6080-33-7
[Synonyms]

SINOMENINE HCL
Cucoline hydrochloride
Kukoline hydrochloride
Sinomenine Hydrocloride
Tuduranine Hydrochloride
SINOMENINE HYDROCHLORIDE
Sabianine A hydrochloride
Sinomenine Hydrochloride >
(9α,13α,14α)- 7,8-Didehydro-4- hydroxy-3,7-diMet
Sinomenine hydrochloride (Cucoline hydrochloride)
TIANFU-CHEM CAS:6080-33-7 SINOMENINE HYDROCHLORIDE
hydroxy-dimethoxy-methyl-BLAH-azatetracyclo[BLAH]hexadeca-BLAH,BLAH,BLAH,BLAH-tetraenone
(9a,13a,14a)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydrochloride
7,8-Didehydro-4-hydroxy-3,7-diMethoxy-17-Methyl- 9α,13α,14α-Morphinan-6-one Hydrochloride
9α,13α,14α-Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride
[Molecular Formula]

C19H24ClNO4
[MDL Number]

MFCD01714307
[MOL File]

6080-33-7.mol
[Molecular Weight]

365.85
Chemical PropertiesBack Directory
[Melting point ]

231.0 to 235.0 °C
[storage temp. ]

2-8°C
[solubility ]

H2O: soluble20mg/mL, clear
[form ]

powder
[color ]

white to beige
[optical activity]

[α]/D -70 to -90°, c = 1 in H2O
[Water Solubility ]

Soluble to 100 mM in water
Safety DataBack Directory
[Safety Statements ]

24/25
[WGK Germany ]

3
[RTECS ]

QD2163000
[HS Code ]

29334900
Hazard InformationBack Directory
[Description]

Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.
[Chemical Properties]

White Solid
[Uses]

Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect.
[Purification Methods]

Crystallise the salt from water (1g/1.5mL) or EtOH. The free base [115-53-7] M 329.4, has m 161o (from EtOH) (and again at 182o) after crystallisation from *C6H6, and [] D 20 -78.9o (c 1, EtOH). The picrate has m 159-162o(dec) (from H2O). [Beilstein 21 II 470, 21 III/IV 6670.]
Spectrum DetailBack Directory
[Spectrum Detail]

SINOMENINE HYDROCHLORIDE(6080-33-7)MS
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