| Identification | Back Directory | [Name]
FC 131 | [CAS]
606968-52-9 | [Synonyms]
FC131,FC-131
cyclo(2Nal-Gly-D-Tyr-Arg-Arg)
Cyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl] | [Molecular Formula]
C36H47N11O6 | [MDL Number]
MFCD28160535 | [MOL File]
606968-52-9.mol | [Molecular Weight]
729.83 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml | [form ]
Powder | [pka]
9.89±0.15(Predicted) | [Water Solubility ]
Soluble to 2 mg/ml in water |
| Hazard Information | Back Directory | [Description]
C-X-C chemokine receptor 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 (SDF-1) which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis. FC 131 is an inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) and also blocks HIV-induced cytopathogenicity (EC50 = 73 nM). FC 131 derivatives can be used for imaging CXCR4 and elucidating its function. | [Uses]
Cyclo[3-?(2-?naphthalenyl)?-?L-?alanylglycyl-?D-?tyrosyl-?L-?arginyl-?L-?arginyl] is a CXCR4 antagonist with anti-HIV properties. | [Definition]
ChEBI: Cyclo[3-(2-naphthalenyl)-l-alanylglycyl-d-tyrosyl-l-arginyl-l-arginyl] is an oligopeptide. |
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DC Chemicals
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