| Identification | Back Directory | [Name]
DCEBIO | [CAS]
60563-36-2 | [Synonyms]
DCEBIO
5,6-DICHLORO-1-ETHYL-1H-BENZO[D]IMIDAZOL-2(3H)-ONE
5,6-DICHLORO-1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE
5,6-DICHLORO-1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-ONE
2H-Benzimidazol-2-one, 5,6-dichloro-1-ethyl-1,3-dihydro- | [Molecular Formula]
C9H8Cl2N2O | [MDL Number]
MFCD04040030 | [MOL File]
60563-36-2.mol | [Molecular Weight]
231.08 |
| Chemical Properties | Back Directory | [Melting point ]
205-207 °C(Solv: ethyl acetate (141-78-6)) | [density ]
1.412±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: >10mg/mL | [form ]
solid
| [pka]
10.28±0.30(Predicted) | [color ]
off-white
|
| Hazard Information | Back Directory | [Description]
DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance. | [Uses]
DCEBIO is a small Ca2+sensitive K+ channel (SKCa) agonist. It also stimulate nitric oxide (NO) synthesis and vasodilation in resistance arteries. | [Definition]
ChEBI: DCEBIO is a dichlorobenzene. | [Biological Activity]
Stimulates Cl - secretion via activation of hIK1 K + channels and the activation of an apical Cl - conductance. More potent than its analog 1-EBIO (1-Ethyl-2-benzimidazolinone ). | [storage]
Store at RT |
|
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