| Identification | Back Directory | [Name]
MEPHENESIN | [CAS]
59-47-2 | [Synonyms]
Rhex
Ortol
Sinan
Tolax
Xeral
a1141
Tolcil
Tolsil
Tolsin
Anxine
Avesyl
Avosyl
Avoxil
Avoxyl
bdh312
byk-m1
Myopan
Myopen
Myopna
Myolax
Myoten
Myoxyl
sq1156
Temian
Myanil
Myanol
Myasin
Mephin
A 1141
Daserd
Glytol
Prolax
rp3602
Saserol
Relaxar
Relaxil
Relaxyl
RP 3602
Halabar
Glyotol
Mc 2303
Diloxol
Daserol
Curaril
Mephson
Mephate
SQ 1156
Tolbart
Tokerol
Myoxane
Myosera
Byk-m 1
BDH 312
Atensin
Toloxyn
Tolhart
Torulox
Tolulox
Tolynol
Tolyspaz
Tolydrin
Tolofren
Tolosate
Tolserol
Tolseron
Thoxidil
Myocaine
Myocuran
Myoserol
Myolysin
Nembusen
Nephelor
Noctynol
Oranixon
Oronixon
Tolansin
Moctynol
Myanesin
Mephedan
Mephelor
Mephosal
Mepherol
Mephesin
Dioloxal
Dioloxol
Findolar
Findolor
Curythan
Renarcol
Prolaxin
Proloxin
Relaxant
Sansdolor
Anatensin
Glykresin
Glukresin
Kinavosyl
Mervaldin
Mianesina
Miolisina
Mefensina
Lissephen
Mephensin
Myastenin
Mycocuran
Spasmolyn
Thioxidil
Cresodiol
Tolulexin
MEPHENESIN
ageflexcge
Mefenesina
Lissenphan
Curarythan
Seconesinz
Cresoxydiol
Spartoloxin
Spartoloxyn
Memphenesin
Mephenesine
Ageflex cge
Walco-Nesin
Walko-Nesin
Myodetensin
Myodetensine
Decontractil
Decontractyl
Rex regulans
Rhex regulans
Mephenesin-D5
Cresossidiolo
Rhex 'hobeino'
MEPHENESIN,POWDER
Kresoxypropandiol
CRESOXYPROPANEDIOL
Cresossipropandiolo
glycerylo-tolylether
1-O-(o-Tolyl)glycerol
o-cresolglycerylether
Glyceryl o-Tolyl ether
1-o-Tolylglycerol ether
o-Cresyl glycerol ether
o-Kresol-glycerinaether
o-Cresol glyceryl ether
O-CRESYL-A-GLYCERYL ETHER
A-(O-TOLYL) GLYCERYL ETHER
1-ortho-tolylglycerolether
1-Ortho-tolylglycerol ether
3-(o-tolyloxy)-2-propanediol
3-(O-TOLOXY)-1,2-PROPANEDIOL
alpha-(o-tolyl)glycerylether
glycerol alpha-o-tolyl ether
ALPHA-GLYCERYL-O-CRESYL ETHER
alpha-(o-Tolyl)glyceryl ether
O-CRESYL-ALPHA-GLYCERYL ETHER
3-(o-Tolyloxy)propane-1,2-diol
3-(2-Tolyloxy)-1,2-propanediol
3-(O-TOLYLOXY)-1,2-PROPANEDIOL
1,2-Propanediol, 3-(o-tolyloxy)-
3-(2-Methylphenoxy)-1,2-propandiol
3-(ORTHO-TOLYLOXY)-1,2-PROPANEDIOL
3-[2-METHYLPHENOXY]-1,2-PROPANEDIOL
3-(2-methylphenoxy)propane-1,2-diol
3-(o-Methylphenoxy)-1,2-propanediol
1,2-Propanediol, 3-(2-methylphenoxy)-
1 2-DIHYDROXY-3-(2-METHYLPHENOXY) PROPANE
alpha,beta-Dihydroxy-gamma-(2-methylphenoxy)propane
Mephenesin,iGluR,inhibit,Ionotropic glutamate receptors,Inhibitor | [EINECS(EC#)]
200-427-4 | [Molecular Formula]
C10H14O3 | [MDL Number]
MFCD00004718 | [MOL File]
59-47-2.mol | [Molecular Weight]
182.22 |
| Chemical Properties | Back Directory | [Melting point ]
69-71 °C(lit.)
| [Boiling point ]
153-154 °C4 mm Hg(lit.)
| [density ]
1.0966 (rough estimate) | [refractive index ]
1.5320 (estimate) | [Fp ]
153-154°C/4mm | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in alcohol | [form ]
Solid | [pka]
13.52±0.20(Predicted) | [color ]
White | [Merck ]
14,5850 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22-36 | [Safety Statements ]
26 | [WGK Germany ]
2
| [RTECS ]
TZ1225000
| [HS Code ]
2909498090 | [Toxicity]
LD50 in mice, rats, hamsters (mg/kg): 471, 283, 322 i.p.; 990, 945, 821 orally (Roszkowski); LD50 in mice (mM/kg): 2.83 i.p.; 10.53 orally (Dresel, Slater) |
| Hazard Information | Back Directory | [Originator]
Tolserol,Squibb,US,1948 | [Uses]
muscle relaxant (skeletal) | [Definition]
ChEBI: 1-(2-methylphenyl)glycerol is a glycerol ether in which a single 2-methylphenyl group is attached at position 1 of glycerol via an ether linkage. It is an aromatic ether and a glycerol ether. It is functionally related to an o-cresol. | [Manufacturing Process]
Into an iron or copper reaction vessel having an efficient stirring device and furnished with a refluxing column and condenser, were charged 330 lb of high quality meta-cresol and 150 lb of glycerol, together with 25 lb of sodium acetate to serve as the catalyst in the reaction. The reaction mixture, of this composition, was then heated to 250°C. The water of the reaction distilled off during the heating as the ether formation proceeded, this removal of water from the reaction chamber being promoted by the presence of the excess of phenol, some of which also continued to distill over. Towards the end of the reaction, after about 12 hours, when about 60% of the glycerol had been converted, at which point the reaction slowed down and the distillate was mainly cresol, the batch was cooled and 50 gallons of water were added to it along with 150 lb of xylene. As the result of these additions and the cooling down of the material the batch stratified into an aqueous layer containing unreacted glycerol, polyglycerols and sodium acetate, and a nonaqueous layer containing the ethers that had been formed in the reaction, together with unreacted cresol which remained in the reaction chamber, dissolved in the xylene that had been added to the batch. The aqueous layer was then separated and the water content removed therefrom by evaporation to a degree suitable for the recovery of the glycerol and sodium acetate contents of the layer, for their reuse in the process in a succeeding batch therein. The separated nonaqueous layer containing the ethers was distilled to recover the xylene and cresol contents respectively as the early fractions of the layer thus subjected to distillation. The cresol thus recovered, together with the cresol recovered from the distillate obtained during the heating of the reaction mixture, was returned to the process for reuse in a succeeding batch. Redistillation of the ether mixture recovered is usually necessary and desirable, particularly from the point of view of removing last traces of cresol therefrom. The yield of mixed ethers in this example was about 200 lb, in the relative proportions stated of about 70 parts of monoether to 30 of diether. | [Brand name]
Tolserol (Bristol-Myers Squibb);Bioglan m/q;Decontracyl-baum;Geno-sal;Glykresinum;Glyptol;Kencaps;Mefentil;Mepha-gesic;Mephesol;Midisalb-m;Myocalm;Myolisysin;Neo-xoline-m;Nochyrol;Relaxil-g;Rhex "hobein";Salimed compound;Walconesin. | [Therapeutic Function]
Muscle relaxant | [World Health Organization (WHO)]
Mephenesin, a centrally acting muscle relaxant and sedative, was
introduced in 1948 and its use has subsequently been associated with some of the
undesirable features of barbiturate use. It is of limited efficacy since it is shortacting
and does not relieve the spasticity associated with chronic neurological
disorders. It has therefore been largely superseded by benzodiazepines but it
remains available in some countries. |
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