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ChemicalBook--->CAS DataBase List--->5870-29-1

5870-29-1

5870-29-1 Structure

5870-29-1 Structure
IdentificationBack Directory
[Name]

CYCLOPENTOLATE HYDROCHLORIDE
[CAS]

5870-29-1
[Synonyms]

Alnide
Zyklolat
cyclogyl
Mydplegic
Ak-Pentolate
Cyclopentolate HCl USP
LABOTEST-BB LT00244824
Cyclogyl hydrochloride
CYCLOPENTOLATE HYDROCHLORIDE
-2-phenylacetate hydrochloride
ethyl 2-(1-hydroxycyclopentyl)
CYCLOPENTOLATEHYDROCHLORIDE,USP
Cyclopentolate hydrochloride CRS
Cyclopentolate Hydrochloride (300 mg)
Cyclopentolate for system suitability CRS
Cyclopentolate hydrochloride EP Impurity C
2-dimethylaminoethyl 1-hydroxy-α-phenylcyclopentaneacetate
alpha-(1-hydroxycyclopentyl)-benzeneaceticaci2-(dimethylamino)ethylest
β-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate hydrochloride
beta-dimethylaminoethyl(1-hydroxycyclopentyl)phenylacetatehydrochloride
2-(Dimethylamino)ethyl 1-hydroxy-α-phenylcyclopentaneacetate hydrochloride
N,N-Dimethylaminoethyl-a-(1-Hydroxycyclopentyl)phenylacetate hydrochloride
2-(2-(1-hydroxycyclopentyl)-2-phenylacetoxy)ethyldimethylammonium chloride
2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate hydrochloride
2-(dimethylamino)ethyl1-hydroxy-alpha-phenylcyclopentaneacetatehydrochlorid
cyclopentaneaceticacid,1-hydroxy-alpha-phenyl-,2-(dimethylamino)ethylester,
2-DIMETHYLAMINOETHYL 1-HYDROXY-ALPHA-PHENYLCYCLOPENTANEACETATE HYDROCHLORIDE
2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenyl-ethanoate hydrochloride
2-(Dimethylamino)ethyl (2RS)-(1-hydroxycyclopentyl)-(phenyl)acetate hydrochloride
2-(1-hydroxycyclopentyl)-2-phenyl-acetic acid 2-dimethylaminoethyl ester hydrochloride
1-Hydroxy-α-phenylcyclopentane acetic acid, 2-[dimethylamino] ethyl ester hydrochloride
Cyclopentaneacetic acid, 1-hydroxy-a-phenyl-, 2-(dimethylamino)ethyl ester hydrochloride (8CI)
Benzeneacetic acid, a-(1-hydroxycyclopentyl)-,2-(diMethylaMino)ethyl ester, hydrochloride (1:1)
[EINECS(EC#)]

227-521-8
[Molecular Formula]

C17H26ClNO3
[MDL Number]

MFCD00079048
[MOL File]

5870-29-1.mol
[Molecular Weight]

327.85
Chemical PropertiesBack Directory
[Melting point ]

137-141°
[storage temp. ]

Inert atmosphere,Room Temperature
[solubility ]

Very soluble in water, freely soluble in ethanol (96 per cent). It shows polymorphism (5.9).
[form ]

neat
[color ]

White to Off-White
Safety DataBack Directory
[WGK Germany ]

2
[RTECS ]

GY2450000
[HS Code ]

2922190900
Hazard InformationBack Directory
[Description]

Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively). It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM, respectively). Formulations containing cyclopentolate have been used to induce pupil dilation and to prevent the eye from accommodating for near vision.
[Chemical Properties]

White Solid
[Originator]

Cyclogyl,Schieffelin,US,1953
[Uses]

A mydriatic
[Uses]

antitussive
[Uses]

antiviral
[Uses]

Mydriatic;Cholinergic receptor antagonist
[Definition]

ChEBI: Cyclopentolate hydrochloride is the hydrochloride salt of cyclopentolate. It is used to produce mydriasis (excessive dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) for opthalmic diagnostic procedures. It acts more quickly than atropine and has a shorter duration of action. It has a role as a mydriatic agent, a parasympatholytic, a diagnostic agent and a muscarinic antagonist. It contains a cyclopentolate.
[Manufacturing Process]

To a well stirred suspension of 9 g of sodium phenyl acetate and 2.4 g of magnesium turnings in 25 cc of anhydrous ether, a solution of 9.4 cc of isopropyl bromide in 50 cc of anhydrous ether are added. The mixture is refluxed for one hour (during which time propane is evolved) and then 5 cc of cyclopentanone in 25 cc of anhydrous ether are added dropwise. The mixture is then refluxed for one hour and poured over ice water containing some hydrochloric acid. The ether solution is separated and extracted with 200 cc of 5% sodium hydroxide. The alkaline solution on acidification gives the free acid which is filtered off, dried in a desiccator and recrystallized from a mixture of ethylene dichloride and petroleum ether.
The product is 2-phenyl-2-(1-hydroxycyclopentyl)ethanoic acid, melting at 95° to 97°C. Of this product, 4.5 g in 30 cc of dry isopropyl alcohol are refluxed for 16 hours with 2.5 g of β-chloroethyl dimethyl amine. The solution is cooled and filtered clear from the solid by-product. The solvent is removed under reduced pressure on the steam bath and the residue is washed with anhydrous ether. It is dissolved in ethyl acetate from which it crystallizes. It is the hydrochloride of β-(dimethylamino)ethyl ester of 2-phenyl-2-(1- hydroxycyclopentyl) ethanoic acid, melting at 134° to 136°C.
[Brand name]

Akpentolate (Akorn); Cyclogyl (Alcon); Pentolair (Bausch & Lomb); Pentolair (Pharmafair).
[Therapeutic Function]

Anticholinergic (ophthalmic)
[General Description]

Cyclopentolatehydrochloride, 2-dimethylaminoethyl 1-hydroxy- -phenylcyclopentaneacetatehydrochloride (Cyclogyl), is a crystalline,white, odorless solid that is very soluble in water,easily soluble in alcohol, and only slightly soluble in ether.A 1% solution has a pH of 5.0 to 5.4.
Cyclopentolate hydrochloride has one half of the antispasmodicactivity of atropine and is nonirritating when instilledrepeatedly into the eye. If not neutralized after the refractionstudies, its effect dissipates within 24 hours. Neutralizationwith a few drops of pilocarpine nitrate solution, 1% to 2%,often results in complete recovery in 6 hours. It is supplied asa ready-made ophthalmic solution in concentrations of either0.5% or 2%.
[Clinical Use]

Cyclopentolate Hydrochloride is used only for its effects on the eye, where it acts asa parasympatholytic. When placed in the eye, it quickly producescycloplegia and mydriasis. Its primary field of usefulnessis in refraction studies. Cyclopentolate hydrochloridecan be used, however, as a mydriatic in the management ofiritis, iridocyclitis, keratitis, and choroiditis. Although itdoes not seem to affect intraocular tension significantly, it isbest to be very cautious with patients with high intraocularpressure and with elderly patients with possible unrecognizedglaucomatous changes.
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