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ChemicalBook--->CAS DataBase List--->58117-94-5

58117-94-5

58117-94-5 Structure

58117-94-5 Structure
IdentificationBack Directory
[Name]

4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (1:1:), (6aR)-
[CAS]

58117-94-5
[Synonyms]

4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (1:1:), (6aR)-
[Molecular Formula]

C17H20ClNO3
[MOL File]

58117-94-5.mol
[Molecular Weight]

321.8
Chemical PropertiesBack Directory
[solubility ]

DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml
[form ]

A crystalline solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS07,GHS08
[Signal word ]

Danger
[Hazard statements ]

H302+H312+H332-H334-H317
[Precautionary statements ]

P261-P264-P270-P271-P272-P280-P284-P301+P312-P330-P302+P352-P304+P340-P362+P364-P333+P313-P321-P342+P311-P363-P501
Hazard InformationBack Directory
[Description]

(?)-Apomorphine is a non-selective dopamine receptor agonist that exhibits pKi values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively.1,2 It produces biphasic effects on locomotor activity and displays anti-parkinsonian and neuroprotective actions.1,3,4
[References]

1. Millan, M.J., Maiofiss, L., Cussac, D., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes J. Pharmacol. Exp. Ther. 303(2),791-804(2002).
2. Seeman, P., Grigoriadis, D.E., and Niznik, H.B. Selectivity of agonists and antagonists at D2 dopamine receptors compared to D1 and S2 receptors Drug Dev. Res. 9,63-69(1986).
3. Newman-Tancredi, A., Cussac, D., Audinot, V., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-adrenoceptor J. Pharmacol. Exp. Ther. 303(2),805-814(2002).
4. Schechter, M.D., Rosecrans, J.A., and Glennon, R.A. Comparison of behavioral effects of cathinone, amphetamine and apomorphine Pharmacol. Biochem. Behav. 20(2),181-184(1984).
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