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ChemicalBook--->CAS DataBase List--->579492-81-2

579492-81-2

579492-81-2 Structure

579492-81-2 Structure
IdentificationBack Directory
[Name]

BAX INHIBITING PEPTIDE V5 (BIP-V5)
[CAS]

579492-81-2
[Synonyms]

Val-Pro-Met-Leu-Lys
VAL-PRO-MET-LEU-LYS;BIP-V5
BAX INHIBITOR PEPTIDE V5, >99%
Bax inhibitor peptide V5 (BIP-V5)
BAX INHIBITING PEPTIDE V5 (BIP-V5)
L-Lysine, L-valyl-L-prolyl-L-methionyl-L-leucyl-
VAL-PRO-MET-LEU-LYS;BIP-V5;BAX INHIBITING PEPTIDE V5
BAX Inhibiting Peptide V5 >=97% (HPLC), lyophilized powder
Bax inhibitor peptide V5,Val-Pro-Met-Leu-Lys, BIP-V5,BAX Inhibiting Peptide V5, >99%
[Molecular Formula]

C27H50N6O6S
[MDL Number]

MFCD04974826
[MOL File]

579492-81-2.mol
[Molecular Weight]

586.79
Chemical PropertiesBack Directory
[Boiling point ]

907.2±65.0 °C(Predicted)
[density ]

1.185±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

≥29.35 mg/mL in DMSO; insoluble in EtOH; ≥91.4 mg/mL in H2O
[form ]

lyophilized powder
[pka]

3.31±0.10(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

Bax inhibitor peptide V5 is an inhibitor of Bax. It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-ĸB p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 μM. It inhibits apoptosis induced by etoposide (Item No. 12092) in Hep3B human hepatoma cells when used at a concentration of 200 μM. Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation. Bax inhibitor peptide V5, when used at a concentration of 100 μM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).
[Biochem/physiol Actions]

BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet and anti-cancer drug.
[References]

[1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357.
[2]. rivas-carrillo jd, soto-gutierrez a, navarro-alvarez n, et al. cell-permeable pentapeptide v5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. diabetes, 2007, 56(5): 1259-1267.
Spectrum DetailBack Directory
[Spectrum Detail]

BAX INHIBITING PEPTIDE V5 (BIP-V5)(579492-81-2)MS
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