| Identification | Back Directory | [Name]
Propanamide, 3-amino-N-2-(1H-imidazol-4-yl)ethyl-, dihydrochloride | [CAS]
57022-38-5 | [Synonyms]
Alistin
Carcinine DiHCl
Decarboxylation carnosine
N-(2-(1H-Imidazol-5-yl)ethyl)-3-aminopropanamide dihydrochloride
3-Amino-N-[2-(1H-imidazol-4-yl)ethyl]propanamide dihydrochloride
Propanamide, 3-amino-N-2-(1H-imidazol-4-yl)ethyl-, dihydrochloride | [EINECS(EC#)]
-0 | [MDL Number]
MFCD22200567 | [MOL File]
57022-38-5.mol |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
H2O: >15mg/mL | [form ]
powder | [color ]
white to beige | [InChI]
InChI=1S/C8H14N4O.2ClH/c1-2-11-8(13)6(3-9)7-4-10-5-12-7;;/h4-6H,2-3,9H2,1H3,(H,10,12)(H,11,13);2*1H | [InChIKey]
WGTMERJVZVYSBG-UHFFFAOYSA-N | [SMILES]
C(NCC)(=O)C(C1=CNC=N1)CN.[H]Cl.[H]Cl |
| Hazard Information | Back Directory | [Uses]
Carcinine dihydrochloride(57022-38-5) is a benzylamine derivative produced by the reaction of malic acid with dehydroascorbic acid. It has anti-aging, antioxidant, anti-inflammatory, protective and sunscreen properties. It also protects against premature aging, UV-induced damage and apoptosis. It is commonly used in anti-aging formulations, especially for sensitive skin. In addition, Carcinine dihydrochloride has been used to study its effects on dopaminergic neuronal degeneration.
| [Biological Activity]
Carcinine dihydrochloride (β-alanyl histamine,57022-38-5) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins.
Carcinine can scavenge a toxic product, called 4-hydroxynonenal (4-HNE), obtained during lipid oxidation. It has a protective role from oxidative damage on photoreceptor cells. Carcinine also exhibits lipid-peroxidase activity.
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