| Chemical Properties | Back Directory | [Boiling point ]
422.6±18.0 °C(Predicted) | [density ]
0.960±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml | [form ]
A crystalline solid | [pka]
2.97±0.21(Predicted) |
| Hazard Information | Back Directory | [Description]
2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA; ).1,2 It induces DNA release from primary human neutrophils.2 2-chloro Stearic acid is toxic to C. quinquefasciatus larvae (LC50 = <1 ppm).3
| [Uses]
2-Chlorooctadecanoic acid (2-Chlorostearic acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1]. | [storage]
Store at -20°C | [References]
1. Wang, W.Y., Albert, C.J., and Ford, D.A. α-Chlorofatty acid accumulates in activated monocytes and causes apoptosis through reactive oxygen species production and endoplasmic reticulum stress Arterioscler. Thromb. Vasc. Biol. 34(3),526-532(2014).
2. Palladino, E.N.D., Katunga, L.A., Kolar, G.R., et al. 2-Chlorofatty acids: Lipid mediators of neutrophil extracellular trap formation J. Lipid. Res. 59(8),1424-1432(2018).
3. Hwang, Y.-S., Darwazeh, H.A., and Navvab Gojrati, H.A. Overcrowding factors of mosquito larvae - larvicidal activity of substituted alkanoic acids and their esters Proc. Pap. Annu. Conf. Calif. Mosq. Control Assoc. 45,160-161(1977). |
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