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ChemicalBook--->CAS DataBase List--->5627-05-4

5627-05-4

5627-05-4 Structure

5627-05-4 Structure
IdentificationBack Directory
[Name]

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
[CAS]

5627-05-4
[Synonyms]

dihydrouridine
Uridine, 5,6-dihydro-
Uridine Impurity 28(5,6-Dihydrouridine)
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
[Molecular Formula]

C9H14N2O6
[MDL Number]

MFCD00047490
[MOL File]

5627-05-4.mol
[Molecular Weight]

246.22
Chemical PropertiesBack Directory
[density ]

1.614±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 16 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
[form ]

A crystalline solid
[pka]

12.40±0.20(Predicted)
[color ]

White to off-white
[Stability:]

Hygroscopic
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[HS Code ]

2934999090
Hazard InformationBack Directory
[Uses]

5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%) (T310250), which is a derivative of Uridine (U829910). Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.
[Definition]

ChEBI: The uridine derivative obtained by formal hydrogenation of the endocyclic double bond in the uracil ring.
[storage]

Store at -20°C
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