| Identification | Back Directory | [Name]
MOLLUGIN | [CAS]
55481-88-4 | [Synonyms]
MOLLUGIN
Rubimaillin
MOLLUGIN(SH)
Mollugin/rubiMaillin
RUBIMAILLIN; MOLLUGIN
6-hydroxy-2, 2-dimethyl-, methylester
Mollugin, 98%, from Rubia cordifolia L.
2H-Naphtho[1,2-b]pyran-5-carboxylic acid
Methyl 6-hydroxy-2,2-dimethylbenzo[h]chromene-5-carboxylate
Methyl 6-Hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
6-Hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylic Acid Methyl Ester
2-DiMethyl-6-hydroxy-2H-naphtho[1,2-b]pyran-5-carboxylic acid Methyl ester
2,2-Dimethyl-6-hydroxy-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester
6-Hydroxy-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester
2H-Naphtho[1,2-b]pyran-5-carboxylic acid, 6-hydroxy-2,2-dimethyl-, methyl ester | [EINECS(EC#)]
683-209-5 | [Molecular Formula]
C17H16O4 | [MDL Number]
MFCD02752331 | [MOL File]
55481-88-4.mol | [Molecular Weight]
284.31 |
| Chemical Properties | Back Directory | [Melting point ]
132～134℃ | [Boiling point ]
453.2±45.0 °C(Predicted) | [density ]
1.239±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [pka]
8.40±0.40(Predicted) | [color ]
Yellow to Green |
| Hazard Information | Back Directory | [Uses]
Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models. | [Definition]
ChEBI: Rubimaillin is a benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. It has a role as a plant metabolite, an acyl-CoA:cholesterol acyltransferase 2 inhibitor, a NF-kappaB inhibitor, an antineoplastic agent, an apoptosis inducer, a neuroprotective agent and an anti-inflammatory agent. It is a benzochromene, a methyl ester and a member of phenols. | [Biological Activity]
Mollugin displays inhibitory activity in arachidonic acid- and collagen-induced platelet aggregation. Mollugin has been reported to inhibit cancer cell proliferationand has other biological activities including anti-inflammatory and apoptotic effects. |
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