| Identification | Back Directory | [Name]
[1R,5S,(-)]-4-Methyl-1-isopropylbicyclo[3.1.0]hexa-3-ene-2-one | [CAS]
546-78-1 | [Synonyms]
Thujenone
Thujen-2-one
(-)-Umbellulone
(1R,5S)-(-)-3-Thujen-2-one
(-)-Umbellulone >=98% (HPLC)
(1R, 5S)-4-Methyl-1-propan-2-ylbicyclo(3.1.0)hex-3-en-2-one
[1R,5S,(-)]-4-Methyl-1-isopropylbicyclo[3.1.0]hexa-3-ene-2-one | [MDL Number]
MFCD26961114 | [MOL File]
546-78-1.mol |
| Hazard Information | Back Directory | [Definition]
ChEBI: Umbellulone is a ketone. | [Biochem/physiol Actions]
(-)-Umbellulone, isolated from the"headache tree" Umbellularia californica Nutt, is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. (-)-Umbellulone activates TRPA1 channels on nociceptive trigeminal afferents, resulting in release of CGRP and CGRP-mediated neurogenic vasodilatation, causing a painful cold sensation and headache/migraine. | [storage]
Store at -20°C |
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