| Identification | Back Directory | [Name]
12(S)-HETE | [CAS]
54397-83-0 | [Synonyms]
12(S)-HETE
(s)-12-hete
12(S)-HETE MaxSpecStandard
12(S)-HETE Lipid Maps MS Standard
(S)-12-Hydroxyeicosatetraenoic acid
12-L-Hydroxy-5,8,10,14-eicosatetraenoic Acid
12(S)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID
12(S)-hydroxy-(5Z,8Z,10E,14Z)-*eicosatetraenoic A
12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID
(12S,5Z,8Z,10E,14Z)-12-Hydroxyeicosatetraenoic acid
12(S)-HYDROXY-(5Z,8Z,10E,14Z)-*EICOSATET RAENOIC ACI
[S-(E,Z,Z,Z)]-12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
(5Z,8Z,10E,12S,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic acid
(5Z,8Z,10E,12S,14Z)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid
12(S)-HETE;12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID
5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (5Z,8Z,10E,12S,14Z)- | [EINECS(EC#)]
200-578-6 | [Molecular Formula]
C20H32O3 | [MDL Number]
MFCD00036916 | [MOL File]
54397-83-0.mol | [Molecular Weight]
320.47 |
| Chemical Properties | Back Directory | [Boiling point ]
487.7±45.0 °C(Predicted) | [density ]
0.984±0.06 g/cm3(Predicted) | [Fp ]
14 °C | [storage temp. ]
-20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml | [form ]
Liquid. | [pka]
4.75±0.10(Predicted) | [color ]
Colorless to light yellow | [BRN ]
2656104 |
| Hazard Information | Back Directory | [Description]
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.1 It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM.2,3
12(S)-HETE MaxSpec® standard is a quantitative grade standard of 12(S)-HETE (Item No. 34570) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 12(S)-HETE MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality. | [Uses]
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM. | [Uses]
A fatty acid metabolite of arachidonic acid (A765000). Potential biomarker for asthma monitoring and diagnosis. Stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Used in the study of mechanisms controlling cell cycle arrest and induction of apoptosis in prostate cancer cells via 12-lipoxygenase inhibition.. | [Definition]
ChEBI: A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds. | [Biochem/physiol Actions]
12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma. | [storage]
Store at -20°C |
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Sigma-Aldrich
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Alfa Chemistry
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Energy Chemical
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http://www.energy-chemical.com |
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