| Identification | Back Directory | [Name]
NH-(PEG1-OH)2 | [CAS]
54384-47-3 | [Synonyms]
NH-bis-PEG2
NH-(PEG1-OH)2
NH-bis(PEG1-OH)
Ethanol, 2,2'-[iminobis(2,1-ethanediyloxy)]bis-
2-(2-{[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol | [Molecular Formula]
C8H19NO4 | [MDL Number]
MFCD00239212 | [MOL File]
54384-47-3.mol | [Molecular Weight]
193.24 |
| Chemical Properties | Back Directory | [Boiling point ]
128 °C(Press: 0.02 Torr) | [density ]
1.090±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
14.09±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
NH-bis(PEG1-OH) can be used to conjugate with carboxylic acid in the presence of HATU or EDC | [Biological Activity]
NH-bis(PEG1-OH) is a non-cleavable 2-unit PEG ADC linker for the synthesis of antibody drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used for PROTAC synthesis. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
| Non-cleavable < span> | PEGs | |
|
|