| Identification | Back Directory | [Name]
Meptazinol | [CAS]
54340-58-8 | [Synonyms]
MEPTAZINOL
MeptaMizol
Meptazinol A
Meptazinol-13C-d3
Meptazinol USP/EP/BP
MEPTAZINOL 54340-58-8
3-(3-ethyl-1-Methylazepan-3-yl)phenol
3-(3-ethylhexahydro-1-methyl-1h-azepin-3-yl)-phenol
3-(1-Methyl-3-ethylhexahydro-1H-azepine-3-yl)phenol
Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-
(+/-)-3-(3-ethyl-1-Methylhexahydro-1H-azepin-3-yl)phenol | [EINECS(EC#)]
259-109-9 | [Molecular Formula]
C15H23NO | [MDL Number]
MFCD00864339 | [MOL File]
54340-58-8.mol | [Molecular Weight]
233.35 |
| Hazard Information | Back Directory | [Originator]
Meptid,Wyeth,UK,1983 | [Uses]
Analgesic. | [Definition]
ChEBI: 3-(3-ethyl-1-methyl-3-azepanyl)phenol is a member of azepanes. | [Manufacturing Process]
2-(m-Methoxyphenyl)butyronitrile in dry ether was added to a stirred suspension of sodium amide in liquid ammonia. The mixture was stirred for 30 minutes then ethyl-4-iodobutyrate (99.25 g, 0.4 mol) in dry ether (200 ml) was added dropwise. The mixture was stirred at the temperature of refluxing liquid ammonia for 5 hours. Ammonium chloride (10 g) was added and the mixture allowed to warm to room temperature. Water (300 ml) was added, the organic layer separated, washed with water, 2 N sulfuric acid and water. After drying over magnesium sulfate and removing the ether, the product was distilled yielding ethyl 5-cyano-5-(mmethoxyphenyl)heptanoate.
That material was hydrogenated in cyclohexane using a Raney nickel catalyst. The product after distillation was recrystallized from ethyl acetate affording 10.0 g of 6-ethyl-(m-methoxyphenyl)hexahydro-2H-azepin-2one, MP 87°C to 88°C.
The azepinone (9.1 g) in dry tetrahydrofuran (50 ml) and ether (50 ml) was added dropwise to a stirred suspension of aluminum lithium hydride (7.5 g) in dry ether (50 ml). After heating under reflux for 3 hours the reaction mixture was worked up and distilled yielding 7.66 g of a compound which was a colorless oil, BP 108°C to 110°C/0.01 mm.
That product was then heated under reflux with 50% hydrobromic acid for 1.5
hours. The reaction mixture was evaporated to dryness and reevaporated with
three portions of propan-2-ol. The oil obtained was dissolved in propan-2-ol
and diluted with ether. 3-Ethyl-3-(m-hydroxyphenyl)hexahydro-1H-azepine
was obtained. That material in turn was reductively methylated by
hydrogenation in the presence of formaldehyde in absolute ethanol solution to
give 3-ethyl-3-(m-methoxyphenyl)-1-methylhexahydro-1H-azepine.
The methoxy group was converted to a hydroxy group by refluxing with 80%
HBr giving meptazinol hydrobromide. | [Therapeutic Function]
Analgesic | [Clinical Use]
Opioid analgesic used for moderate to severe pain | [Drug interactions]
Potentially hazardous interactions with other drugs
Antidepressants: possible CNS excitation or
depression with MAOIs - avoid; possible CNS
excitation or depression with moclobemide; possibly
increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with
sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative
effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate
- avoid | [Metabolism]
Meptazinol is extensively metabolised in the liver and is
excreted mainly in the urine as the glucuronide conjugate.
Less than 10% of a dose has been recovered from the
faeces. |
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