| Identification | Back Directory | [Name]
Pipobroman | [CAS]
54-91-1 | [Synonyms]
A-8103
Amedel
Vercyte
NSC-25154
Pipobroman
1,4-Bis(3-bromopropionyl)piperazine
1,4-Bis(3-bromo-1-oxopropyl)piperazine
1,4-Bis(3-bromo-1-oxopropyl)piperadine
1,1'-(1,4-Piperazinediyl)bis[3-bromo]-1-propanone
1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
1-Propanone, 1,1'-(1,4-piperazinediyl)bis[3-bromo-
3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one | [Molecular Formula]
C10H16Br2N2O2 | [MDL Number]
MFCD00866372 | [MOL File]
54-91-1.mol | [Molecular Weight]
356.05 |
| Chemical Properties | Back Directory | [Melting point ]
106-107℃ | [Boiling point ]
487℃ | [density ]
1.691 | [refractive index ]
1.6220 (estimate) | [Fp ]
248℃ | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
-0.56±0.70(Predicted) | [color ]
Crystals from H2O | [EPA Substance Registry System]
Pipobroman (54-91-1) |
| Hazard Information | Back Directory | [Originator]
Vercyte ,Abbott ,US ,1966 | [Uses]
diuretic, antihypertensive | [Definition]
ChEBI: Pipobroman is an N-acylpiperazine that is piperazine in which each of the nitrogens has been acylated by a 3-bromopropionoyl group. An anti-cancer drug. It has a role as an antineoplastic agent and an alkylating agent. It is a N-acylpiperazine, a tertiary carboxamide and an organobromine compound. | [Manufacturing Process]
To a solution of 17.2 g (0.10 mol) of 3-bromopropionyl chloride in 100 ml of anhydrous benzene was added dropwise with stirring a solution of 8.6 g (0.10 mol) of anhydrous piperazine in 20 ml of dry chloroform over a period of 30 minutes. The temperature rose spontaneously to 45°C during the addition. After the temperature ceased to rise, stirring was continued for another hour. The reaction mixture was then filtered to remove the piperazine hydrochloride by-product. The filtrate was evaporated to dryness and the residue recrystallized from ethanol to obtain the desired N,N'-bis-(3bromopropionyl)piperazine as a white crystalline solid melting at 103°C to 104°C. The identity of the product was further established by elemental analysis. | [Brand name]
Vercyte (Abbott). | [Therapeutic Function]
Antineoplastic | [Biological Activity]
Pipobroman is an alkylating agent th at is used as anti-cancer drug. It also has clinical activity in polycythemia vera and thrombocythemia. | [Safety Profile]
Poison by ingestion,subcutaneous and intraperitoneal routes. An experimentalteratogen. Other experimental reproductive effects.Human mutation data reported. When heated todecomposition it emits very toxic fumes of Br- and NOx. | [storage]
Store at -20°C |
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| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|