| Identification | Back Directory | [Name]
lonazolac | [CAS]
53808-88-1 | [Synonyms]
lonazolac
LONAZOLAC CALCIUM
3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid
1H-Pyrazole-4-acetic acid, 3-(4-chlorophenyl)-1-phenyl-
2-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]acetic acid | [EINECS(EC#)]
258-791-5 | [Molecular Formula]
C17H13ClN2O2 | [MDL Number]
MFCD00866046 | [MOL File]
53808-88-1.mol | [Molecular Weight]
312.755 |
| Hazard Information | Back Directory | [Originator]
Irriten,Tosse,W. Germany,1981 | [Definition]
ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 3-(4-chlorophenyl)-1-phenylpyrazol-4-yl group. | [Manufacturing Process]
17.6 g 1-phenyl-3-(p-chlorophenyl)-pyrazol-4-acetonitrile and 180 ml 25%
aqueous hydrochloric acid were mixed and heated to the boiling temperature
under reflux for 6 hours. To the mixture was then added dropwise
concentrated aqueous sodium hydroxide until the pH of the mixture reached a
value in the range from 3 to 5. The free pyrazol-4-acetic acid precipitated
thereby was filtered off, redissolved in dilute aqueous sodium hydroxide, the
solution cleared by treatment with activated carbon, and the pyrazol-4-acetic
acid precipitated by acidifying the solution by the addition of dilute mineral
acid, sulfuric acid. The filtered acid was crystallized from a mixture of ethanol
and water. 17.1 g 1-phenyl-3-(p-chlorophenyl)pyrazol-4-acetic acid, melting at
148°C to 150°C, were obtained, representing a yield of 91%. | [Therapeutic Function]
Antiinflammatory |
|
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