| Identification | Back Directory | [Name]
1,3,5-Trihydroxy-4-prenylxanthone | [CAS]
53377-61-0 | [Synonyms]
5-Trihydroxy-4-prenylxanthone
1,3,5-Trihydroxy-4-prenylxanthone
1,3,5-Trihydroxy-4-(3-Methylbut-2-en-1-yl)-9H-xanthen-9-one
1,3,5-Trihydroxy-4-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
9H-Xanthen-9-one, 1,3,5-trihydroxy-4-(3-methyl-2-buten-1-yl)- | [Molecular Formula]
C18H16O5 | [MDL Number]
MFCD20260476 | [MOL File]
53377-61-0.mol | [Molecular Weight]
312.32 |
| Hazard Information | Back Directory | [Description]
1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM.
1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced NF-κB and AP-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of IRAK-1 in the cell membrane to impede TAK1-mediated activation of IKK and MAPKs signal transduction.
3. 1,3,5-Trihydroxy-4-prenylxanthone shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 M, respectively. | [target]
NF-kB | IkB | AP-1 | JNK | ERK | TGF-β/Smad | AChR | IKK |
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