| Identification | Back Directory | [Name]
CYAYKKUWALRRPA-UHFFFAOYSA-N | [CAS]
529493-92-3 | [Synonyms]
CYAYKKUWALRRPA-UHFFFAOYSA-N
Hexopyranosyl bromide, 2,3,4,6-tetraacetate
6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide | [Molecular Formula]
C14H19BrO9 | [MOL File]
529493-92-3.mol | [Molecular Weight]
411.2 |
| Hazard Information | Back Directory | [Biological Activity]
2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
|
|