| Identification | Back Directory | [Name]
DIETHYL BROMOPHOSPHATE | [CAS]
51761-27-4 | [Synonyms]
DIETHYL BROMOPHOSPHATE
diethyl phosphorobromidate
Bromidophosphoric acid diethyl ester
Phosphorobromidic acid, diethyl ester | [Molecular Formula]
C4H10BrO3P | [MDL Number]
MFCD01074583 | [MOL File]
51761-27-4.mol | [Molecular Weight]
217 |
| Hazard Information | Back Directory | [Uses]
Used in β-lactam formation; peptide synthesis; formation of trifluoroacetyl bromide. | [Preparation]
Diethyl phosphorobromidate is prepared in good yield from the reaction between N-Bromosuccinimide and diethyl hydrogen phosphite,1 or from the bromination of Triethyl Phosphite with Bromine at -30 °C to -25 °C.2 It can also be prepared in almost quantitative yield by reacting diethyl hydrogen phosphite with Chlorotrimethylsilane followed by bromine at -78 °C. | [storage]
Highly toxic, corrosive, and a lachrymator. It should be used in a fume hood. It is highly moisture sensitive and undergoes thermal decomposition. It generates toxic byproducts when decomposition occurs. Should be stored under nitrogen in a cool dry place. |
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